One of the most common potency problems is erectile dysfunction, with which many men have to live for a long time. Any types of potency disorders have a strong psychogenic effect on a man.
Most men consider this disease a personal problem and usually don’t consult a doctor. Some of them think that erectile dysfunction is incurable. However, in 95% of cases, erectile dysfunction can be cured. The main thing is to pinpoint the cause of the illness.
Types of Erectile Dysfunction
To achieve adequate potency, it is necessary to have a good blood supply (arterial blood flow) and proper operation of the veins in the penis (some types of poor erection are associated with an increased outflow of venous blood that does not allow maintaining the desired density of cavernous bodies for a long time). From the above, it follows that the first type of a poor erection is the so-called organic or vascular erectile dysfunction.
The hormonal background of men, normal testosterone and prolactin levels provide the correct structure of the male body, the presence of secondary sexual characteristics, the size of the testicles, the male hair type, strength, and endurance. With a decrease in the hormonal background, there is a persistent decline in libido and the presence of potency problems. In medical terms, this condition is called hypogonadism.
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There is primary hypogonadism (most often associated with congenital defects of the endocrine system or genetic diseases) and acquired hypogonadism. The latter is a real scourge of modern men, prone to consuming excessive amounts of calories, alcohol, and tobacco. So, the second type of a poor erection is erectile dysfunction associated with hormonal disorders.
Inability to have an erection because of stress has a powerful effect on the psyche of a man, exacerbating the situation. The development of the so-called failure syndrome is possible. Before the sexual intercourse, there is a strong adrenaline rush, the vessels narrow, and the cumulation of cavernous bodies does not occur. This type of violation is characterized by the fact that it can appear and disappear suddenly, for no apparent reason.
Treating Erectile Dysfunction with Blue Light
Specialists of the Swiss Federal Institute of Technology in Zurich have developed a biotechnological solution to the problem of erectile dysfunction, which is a combination of gene construction and blue light.
Men do not like to talk about erectile dysfunction, but after the age of 30 years old, the frequency of such disorders increases significantly. At the age of 60 years old, more than half of men suffer from an inferior erection or its complete absence.
The main reasons for this include:
- Diseases of the cardiovascular system
- Diabetes mellitus
- Hormonal disorders
- Neurological diseases
- The side effects of various medications
Some men try to solve the problem with the help of so-called blue pills. However, Viagra and its analogs contribute to an increase in the duration of erection but do not start it. In search of a solution to this problem, researchers working under the guidance of Professor Martin Fussenegger have developed a gene therapy approach that allows achieving a stable erection even in the absence of sexual stimulation.
For this, a genetic construct is introduced into the erectile tissue of the penis, which reacts to blue light. Under its action, the precursor molecule (guanosine triphosphate, GTP) is converted into a secondary messenger – cyclic guanosine monophosphate (cGMP), which is part of a number of human organs in the natural state. This ensures the closure of potential-dependent calcium channels, thereby reducing the concentration of calcium ions in the cells, which in turn relaxes muscle cells and increases blood flow to the erectile tissue of the penis. As a result, the penis increases in size and hardens. Gradual cleavage of cGMP by the action of the enzyme phosphodiesterase 5 ensures the decrease of the erection. The blocking of this enzyme’s activity is based on the action of the blue pills, prolonging the erection.
When a therapeutic gene construct is introduced, cGMP production is stimulated not by sexual arousal but by exposure to blue light. This allows dispensing with the usual sexual arousal that triggers an escalating cascade of biochemical signals under normal conditions and is useless in erectile dysfunction. The authors of the study successfully tested the experimental method in male rats. In most cases, after the introduction of the gene construct, the effect of blue light caused an erection in animals, while some of them even had an ejaculation.
The scientists believe that the risk of complications in the application of their proposed approach is minimal. Injections into erectile tissue are the standard approach to the administration of drugs for the treatment of erectile dysfunction. This tissue is weakly sensitive to pain, moreover, the greater part of it is isolated from normal blood flow, which reduces the risk of moving the gene construct throughout the body to a minimum. Moreover, cGMP is quickly broken down in the body.
However, despite the attractiveness of the new approach, it is still very far from practical application. The developers point out the need for carefully planned clinical trials and are currently looking for partners to accelerate this process.
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