The problem with erection is one of the most discussed ailments in the world. It involves millions of men from different parts of the globe. Regardless of age, nation and other properties, it can strike anyone.
Yearly, scientists create different cures or conduct special trials to improve the quality of man erection. Nonetheless, the most dependable method is the administration of PDE-5 inhibitors. These block enzyme PDE5 that disables the relaxation of smooth muscles. One of the most common causes of inappropriate erection is insufficient blood support of the pelvic organs. These inhibitors provide sufficient amounts of blood to reach the proper and lasting erection. Of course, simple usage of these inhibitors will not provoke erection. There is a need in natural reinforcement.
There is another fact about these inhibitors. Safe influence upon the penis, they boost heart as well. Due to the presence of this enzyme in cardiac muscle, it has become an essential subject of therapeutic studies in the sphere of cardiology. However, this affection is still far from clear. Future studies should reveal more about the interactions of PDE-5 and heart maintenance.
Details on Usage
These inhibitors are quite reasonable and safe choice for men with erectile dysfunction, but only for those who do not suffer from other serious diseases. They are the major components of such famous medical remedies against poor erection as Viagra, Cialis, Levitra and so on. Safe effective results in good erection, they are capable to remove difficulties with hypertrophy of definite parts of the heart.
Such powerful remedies have really powerful influence upon all systems of our organism. Therefore, there are special occasions, when its usage is contraindicated for treatment, as it may lead to health complications. Prior to using any remedy that contains Sildenafil, Tadalafil or Vardenafil, it is recommended consulting at a specialist in this sphere.
You have to memorize the next general conditions that make the implementation of PDE-5 inhibitors dangerous for your health. These are:
- Increased sensuality to the inhibitors as a result of specific interaction of your organism to the presence of alien substance in blood.
- Simultaneous usage of cures that contain nitrates.
- Parallel administration of preparations with the same action.
- Definite kinds of alpha-blockers.
- Prostate cancer.
- Recent heart attack, uncontrolled angina and other serious heart ailments and dysfunctions.
- Extremely low levels of blood pressure.
- Alcohol consumption.
The remedies should be cautiously taken by examinees who have dysfunction of liver and/or kidney. Depending on the medication, there exist definite age restrictions. Examinees who have not reached the age of 16-18 years should not intake these remedies.
Mark that there can be other contraindications and restrictions on usage. Everything relies on the certain preparation.
These cures are oral and are to be taken with enough amounts of liquid. The start of action varies from one preparation to another one. Generally, these periods take 15-45 minutes. Sildenafil must be implemented on empty stomach, because food influences the start of action and can remove it for indefinite period. Other inhibitors can be taken regardless of food.
Commonly, the tablets should be taken once per day. However, Tadalafil can be used once in two days, as it has utterly lasting action, which reaches 36 hours.
The usage of such powerful substances does not pass without certain consequences. It has tremendous affection and induces some harmful effects. The first area they affect is cardiovascular system. There is a strong connection between heart and ED. Nevertheless, there take place other health complications too.
Generally, there can develop such adverse reactions:
- Cardiovascular ailments and disorders (heart attacks, uncontrolled heart rate, unstable blood pressure levels and so on).
- Different types of allergies.
- Enhanced sweating.
- Liver and kidney dysfunctions.
- Respiratory ailments.
- Difficult vision (including too great sensuality to light and inability to distinguish out some of the colors).
- Digestive deviations and illnesses of various character.
- Hair loss.
- Troubled urination.
- Priapism or abnormally long erection that reaches 4 hours and more. This can lead to entire loss for erection.
In most occasions, these effects do not take place. Even if they do, their affection in not durable and serious.
Severe adverse effects take place in cases of overdosing, inappropriate combination with some other cures (you have to ask your supervisor about drug interactions) or ignorance of some contraindications.
Miracle Effects of PDE-5 Inhibitors for Heart
It is also worth mentioning that one of the recent studies that has determined that this group of inhibitors has positive effects for one serious abnormality of the heart.
The trial was conducted by the University of Rome Sapienza. Its scholars involved 1622 examinees who suffered from left ventricular hypertrophy. This is a dangerous increasing of heart, which leads to the most grievous outcomes. In the course of the study, the experts have found out that the implementation of PDE-5 inhibitor stopped the growth of the heart. It also prevented the alteration of its shape.
The scholars chose Sildenafil, the main ingredient of Viagra. It is not known whether other inhibitors of this class possess the same effects. Though they derive from one family and have the same action, there are some difference in their influence upon the organism. At any rate, the scholars are targeted at conducting further researches.
This information proves that our specific inhibitors possess positive effects for reproductive and cardiovascular systems. They can maintain them and even cure. However, they should be taken cautiously, as they can harm these systems as well.