Generic Cialis Beats The Records In Potency Recovery, Description, Posology And Administration

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 Table of Contents:


Generic Cialis Beats the Records in Potency Recovery

Medical science has been undertaking active and successful measures against erectile dysfunction since 1998. From the very beginning, men suffering from ED got familiar with Viagra. But time changes a lot of things, including methods and principles of therapy of the bitterest enemy – sexual frustration.

Up to 1998, erectile impairments were treated by means of surgeries, vacuum pumps and other not always efficient, but expensive remedies. But after a real breakthrough in medicine, there appeared a chance to become healthy. Viagra development became a discovery in therapy of erectile dysfunction resulting in its active usage in medicinal practice.

Viagra (drug page) had certainly its advantages and drawbacks; for this purpose, scholars began developing the idea in this direction further. The main goal was provision of the better results than Viagra’s and reduce the negative consequences to minimum. In four years after appearance of the first medication for erectile dysfunction, pharmacists from the renowned company, Eli Lilly, presented a new medicine which supposedly was much more efficient and universal. This idea was proven by many research studies. This new brand acquired the name Cialis.

Generic Cialis is an analogue of the famous original drug for potency support. The only thing distinguishing the generic from branded Cialis is price which is in fact more affordable and beneficial for most men. The medicine has a strong therapeutic effect and unbelievably fast onset time. Its action lasts more than thirty-six hours. Due to its compatibility with alcoholic beverages, this generic is preferred by the majority of men.

Generic Cialis Description

Since Viagra was placed on shelves of pharmacies, many men suffering from erectile dysfunction gave a sigh of relief. But nowadays, there is another medicine which proves to be more efficient than Viagra – Cialis from Eli Lilly. Generic Cialis is a certified copy of branded Cialis repeating its composition, mechanism of action and effectiveness. The medication surpasses all other analogues for potency restoration and erectile dysfunction considerably with its long-lasting effect and headlong action. One tablet of Generic Cialis is effective within 36 hours. Besides, Generic Cialis may be combined with ethanol which allows many men to stay confident in their sexual strength without any restrictions.

Posology and Administration

Generic Cialis is a remedy for therapy of erectile disorders falling into the group of selective PDE5 inhibitors. When sexual arousal causes local release of nitrogen oxide, inhibition of PDE5 with tadalafil (active substance of Generic Cialis) leads to increase of cyclic guanosine monophosphate level in cavernous bodies of penis. Due to this fact, relaxation of unstriated muscles of arteries and blood stream to penis tissues causes erection. Tadalafil is not effective in case of absence of sexual stimulation. The research studies have shown that Generic Cialis and its main component, tadalafil, is a selective inhibitor of PDE5. PDE5 is enzyme located in smooth muscle cells of cavernous bodies, in unstriated muscles of internal organs’ cells, in skeletal muscles, thrombocytes, kidneys, lungs and cerebellum.

Posology and Administration

Tadalafil effect on PDE5 is the most active in comparison with other phosphodiesterases. Tadalafil is 10 000 times more active in regards to PDE5, than in regards to PDE1, PDE2, PDE4 which are localized in heart, cerebrum, blood vessels, liver and other organs. Tadalafil is 10 000 times more active while blocking of PDE5, than PDE3 – enzyme which is situated in heart and blood vessels. This selectivity concerning PDE5 in comparison with PDE3 has a huge importance, since PDE3 is enzyme taking part in contraction of cardiac muscle. Besides, tadalafil (Generic Cialis) is 700 times more active in regards to PDE5, than PDE6 located in eye retina which is responsible for photographic transmission. Also, tadalafil is 10 000 times more active with PDE5 as opposed to PDE7-PDE10.

Generic Cialis is efficient within the course of 36 hours. Its effect is seen in 16 minutes after peroral intake in case of sexual excitement. If taken by sound men, tadalafil has no verified alteration of systolic or diastolic pressure in comparison with placebo in prone position (average maximal decrease is 1,6/0,8 mm Hg accordingly) and in standing position (average maximal decrease is 0,2/2,6 mm Hg accordingly). Tadalafil doesn’t cause verified cardiac rate alteration. Generic Cialis doesn’t cause changes in color perception (blue/green) which is explained by its low affinity to PDE6. Besides, tadalafil’s action on acuity of vision, electroretinogram, intraocular pressure and pupil’s size is not observed. There is no clinically significant impact of Generic Cialis on male semen if taken in daily dose within six months.

After peroral intake, tadalafil is fast absorbed. Maximal concentration is generally reached within two hours. Rate and degree of absorption do not depend on food intake. Pharmacokinetics of tadalafil in healthy people is linear according to time and dose. Dosage diapason from 2,5 up to 20mg causes increase of area under the concentration-time curve pro rata with the dose. Css in blood plasma is reached within five days in case of peroral intake once per day.

Generic Cialis pharmacokinetics in patients with impairment of erectile function is analogous to pharmacokinetics of the drug in men without erectile disorders. Volume of distribution is around 63L which indicates the fact that tadalafil gets spread in organism tissues. Therapeutic concentrations of 94 per cent of tadalafil get connected with plasmatic protein. Sound persons appear to have less than 0,005 per cent of introduced dose in semen.

Generic Cialis is metabolized with participation of isoenzyme CYP3 A4. The main circulating metabolite is methyl-catechol-glucoronide which is 13000 times less active in regards to PDE5 than tadalafil; therefore, it is unlikely that this metabolite is clinically significant. Sound men have average clearance of tadalafil equal to 2,5l/h, whereas average half-life elimination time is 17,5 hours. Tadalafil is cleared mainly in the form of inactive metabolites, generally in feces (around 61 per cent) and to a lesser extent in urine (around 36 per cent). Patients suffering from hepatic failure of mind or moderate severity level have area under the concentration-time curve bigger than in healthy people.

Dosage of Generic Cialis is better to be selected by middle-aged men in amount of 20mg. Tablets should be taken at least 16 minutes prior to sexual activity regardless of food intake. Patients are able to have sex anytime within 36 hours after Generic Cialis application in order to determine optimal time of organism response on tadalafil usage. Maximal frequency of tadalafil administration is once a day.

Safety Note for Generic Cialis

Although Generic Cialis is a therapeutic remedy, it has contraindications and side-effects as well. A patient should not neglect these data, since this may result in serious impairments of penis functioning and entire organism. Generic Cialis side-effects are first of all connected with incorrect dosage resulting from self-treatment. The noticeable factor is allergy to some of the components of the active substance. First of all, it is essential to understand that Generic Cialis improves erectile functioning.

What is necessary to remember?

  • Erection itself takes a big impact on heart, and it starts beating faster. Thus, this drug is not to be taken by men suffering from cardio-vascular issues.
  • It is highly important not to administer Generic Cialis in case a patient has already undergone apoplectic and heart attacks or serious cardiac surgeries.
  • Generic Cialis is prohibited to use if a patient is suspected to have leukemia or it has already been diagnosed.
  • The medicine’s intake along with other agents taking impact on erection was not studied; therefore, it is better to administer one agent instead of several of them for security objectives. If erection lasts more than 4-5 hours after Generic Cialis intake, immediate medical attendance is required. Otherwise, a patient may experience many-days erection loss or another organ may be severely damaged.
  • Usage of Generic Cialis for self-medication must be refused, since this drug is first of all a medicine and not a vitamin.
  • Interaction with other medications is examined; therefore, there are some recommendations in regards to Generic Cialis co-administration with other drugs. Hence, ritonavir may prolong and enhance Generic Cialis’s action, thus, their combination is inadmissible. Co-administration of the drug with magnesium hydroxide and aluminum hydroxide causes the decrease of absorption rate. It means that Generic Cialis adverse effect may delay.
  • If Generic Cialis is combined with medications reducing blood pressure rate, the first may enhance their effect. Generic Cialis should be administered under physician’s control in this case.
  • A patient is not to co-administer Generic Cialis with nitrates.
  • Men must avoid using Generic Cialis in case of penis deformation of any etiology. Deformation problem is not treated with Generic Cialis, whereas tissue damage may occur because of medicine’s influence.
  • Young men under 19 years of age should not start administration of this drug, which is directly connected with young age. All impairments in the functioning of erectile system at this age should be discussed with a doctor, since it is of low probability that these impairments could be eliminated with Generic Cialis.
  • The medicine may be combined with alcohol, although this co-intake is not recommended.

Beneficial Offers on Generic Cialis from Canadian Health&Care Mall

Canadian Health&Care Mall canadahealthcaremall.com offers a great variety of generics from such reputed pharmaceutical companies, as Sunrise, Ajanta Pharma, Delta, Cipla, etc. Nevertheless, the most popular medication is Generic Cialis. We have thousands of satisfied customers acknowledging a gratitude to our price policy and service which make their life brighter. It’s no secret that erectile issues and fast sexual intercourse do not give enough pleasure to both partners. Our carrier will deliver Generic Cialis promptly.

You’ll be able to estimate its crucial advantages:

  • Long-term erection for 36-48 hours;
  • Ability to have sex any moment regardless of your affairs and bad mood;
  • No spontaneous erection which may bring a lot of troubles in a public place;
  • Possibility to use Generic Cialis within a therapy course in minimal dosage.

Generic Cialis Just for 1,43 USD per Pack!

Why is it so cheap? Earlier Generic Cialis was available in accredited drug stores and on doctor’s prescription only. A patient had to visit a physician before each purchase, stand in the long line and procure the doctor’s order. Then he had to go to the pharmacy where the drug was available on stock. All people at drug store could hear the aim of patient’s visit. And the situation was far from being pleasant. Besides, patented Cialis is quite expensive. Company-producer added expenses for research studies, trials, brand promotion, technologies development, and the entire process of elaboration to the cost of the medication. Moreover, the company also wanted to derive profit as well. Thus, a common man with average salary can’t afford such expenses.

The original Cialis cost is too dear for most men, although it may be successfully substituted with Generic Cialis. This is an exact copy of the original made in accordance with the same formula. It was issued by a credible renowned pharmaceutical company; therefore, there is no reason to be skeptical about its efficiency and safety. In this case, company has famous in pharmaceutical world name, Delta Enterprises. Generic Cialis price offered by Canadian Health&Care Mall is the most beneficial and affordable for all men. This drug is manufactured according to ready formula. It uses the benefits of widely promoted brand; therefore, it doesn’t require big expenses. A patient saves money, time, energy and nerves.

Generic Cialis Super Pack

As it was mentioned before, Cialis advertising has absorbed huge amounts of money. Necessity to compete with Viagra resulted in growth of Cialis pricing. Although, monopoly of American manufacturers was not long-term. Explosive market growth of Asian-Oceanian countries (especially India where pharmaceutical production is traditionally highly privileged) lead to creation of a number of relatively cheap generics of Cialis. They represent original composition of branded Cialis with addition of vitamin-mineral complex. Hence, final composition of Generic Cialis pill doesn’t violate the patent. Besides, their names are traditionally assonant, but not copy the original. In case you are just starting to get familiar with erection boosting medicines, Canadian Health&Care Mall offers you to try Tadarise 20mg in the form of tablets issued by Sunrise Remedies. This is also a perfect choice for those who want to purchase Cialis generic cheap, since the price for this analogue is one of the lowest.

Big men and tendinous athletes with good metabolism have highly estimated generic Tadarise 40mg with a double dose of active substance. Those men who experienced and realized all advantages of Cialis generics will find Tadalis-sx 20mg and Tadacip 20mg excellent to treat their sexual issues. Unfortunately, Eli Lilly do not give many options: a patient is able to buy only Cialis pills, although, there are the so-called Soft versions of the drug among generics. As opposed to Cialis tablets which need to be drunk with water and taken fasted, Soft variants are merely dissolved in mouth cavity. This method of Cialis Soft administration allows accelerating its absorption and avoiding limitation in beloved food. You may order the following variants of Soft Cialis generics: Vidalista-CT 20mg and TadaSoft 20mg.

Special offer is represented by the drug named Tadalista Super Active 20mg. In case a patient has particularities of digestion preventing from taking traditional pills of Cialis, gelatinous coating of capsules will efficiently deliver active substance to the location of digestion in small bowel. Moreover, Cialis generics in the form of capsules with jelly are distinguished by high absorption rate. The most interesting and useful product of the last generation is considered to be Apcalis-sx Oral Jelly 20mg. It is packed on a special bag with aromatic jelly which may be added to food or beverages.

Generic Cialis Samples for Free

Perception and reaction of each man are individual. Everything that is good for one person may be harmful for another one. Selection of remedies for erectile dysfunction is broad. How can we make a correct choice? Canadian Health&Care Mall offers you an excellent promotion action. According to this action, we distribute samples of Generic Cialis absolutely for free. After you receive a kit, you will be able to test it and expose possible side-effects or confirm its high efficiency.

Make a conscious choice! Generic Cialis is represented in those dosages which are suitable for most men. If required, you may divide a tablet into parts in order to reduce the dose.

Generic Cialis Samples for Free

In order to acquire a free sample of Generic Cialis, you can just phone us or leave a message on the panel of quick order, and specialists from Canadian Health&Care Mall will make sure to call you back. You may take the samples on your own or order them with our carrier. One person gets one trial kit.


It is important:

  • Before you use Generic Cialis, make sure to study the instruction;
  • Do not apply more than one medication per day.

Please, after you tried Generic Cialis, leave a feedback about its action and effectiveness. We appreciate your opinion. Besides, your testimonial will help those who live in other region and has to choose without preliminary test of samples.

Main Ingredients

Active substance of Generic Cialis is tadalafil. The component takes impact on erectile function and is not harmful for patient’s health. If all recommended doses are observed, Generic Cialis will not cause any adverse effects or allergic reactions. Tadalafil acts directly on blood vessels or sexual organ relaxing muscles and causing a strong erection. This substance may be combined with alcoholic beverages in small quantities, as well as with a number of medicinal products.

Apart from tadalafil, Generic Cialis includes the following auxiliary agents: talc, lactose, magnesium stearate, sodium lauryl sulfate, etc. These ingredients do not build up tolerance. Generic Cialis is issued in the form of coated capsules containing 20mg of tadalafil.

Generic Cialis vs Branded Cialis

Every man may come across a potency problem. This may occur due to various causes: incorrect lifestyle, obnoxious habits, various diseases, etc. The causes list is enormous. It goes without saying that sexual issue is quite a delicate problem which is hardly discussed by most men. It is proven that the majority of men feel ashamed of consulting a specialist. As for expensive medications which are able to treat this unpleasant disorder, such as Viagra or Cialis, very often men cannot afford using them. Nevertheless, it is important to know that generics cost will not only bewilder you, but also will never disappoint.

Why is there such a difference between original and generic? In fact, the answer is quite simple. Manufacture of original Cialis takes much time and money, as opposed to Generic Cialis. Moreover, generics are manufactured the same way as the branded original without any differences in the composition. Generic Cialis takes its action as quickly as the original, and in a couple of minutes you will be able to feel it. You may rest assured that the effect will be more than agreeable, since it lasts more than 36 hours. You may not worry about possible erectile disorders within two days. Like the original, this medication has practically no contraindications. Never fear buying Generic Cialis, since it is not counterfeit, but qualitative copy of the original medication.

Five Alternative Ways to Cure Erectile Dysfunction

There are lots of ways to cure male problems with potency:

1. Medicamentous therapy of erectile dysfunction. After this condition was confirmed to be a constant problem, but not a one-time or temporary – this group of medications is called PDE5 inhibitors. Most medications are taken 30 to 60 minutes before sexual intercourse. The most popular is a blue magic pill called Viagra (sildenafil). Other variants are Levitra (vardenafil), Cialis (tadalafil) and Stendra (Avanafil).2. Vacuum implements and vacuum pumps. Vacuum erection devices represent a mechanic way of erection acquisition in men who cannot or do not want to apply medicamentous therapy or it is merely useless. In essence, vacuum system for potency consists of three components: cylinder, pump and clamping ring fixing penis root. Cylinders of vacuum therapy of erectile dysfunction may differ in construction, but they all are glass envelopes made of transparent plastic due to which penis is visible while creation of exhaustion around it.3. Surgical methods for ED:
  • Implants. This is the final variant for men who couldn’t succeed in pharmaceutical treatment and other non-invasive remedies. During operation, prostheses are placed in penis. They take shape of erected sexual organ when it is required or make it firm but not always in vertical position. The most complicated is a three-section version which is hidden completely inside penis and gives it normal outlook. It may be either relaxed or firm according to the action of blow-off valve filling the implant with liquid. Nevertheless, a patient should know that such method of surgery may be infected or rejected by organism. Plus, mechanical damage of the device will require repetitive operation.
  • Vascular surgery. Another variant for men suffering from erectile dysfunction is vascular surgery which corrects some problems with blood vessels causing ED.
4. Biologically active supplements. A doctor will never give official prescription to use biologically active supplements. Their reliability and safety are not confirmed by broad clinical trials. Although some of them may contain sildenafil.5. Alternative medicine. There are very popular methods of ED treatment:
  • Yohimbe;
  • Gingko;
  • Epimedium;
  • Korean red ginseng;
  • Dehydroisoandrosterone;
  • L-arginine.

Generic Cialis Testimonials

Valentine

Generally, I consider myself a healthy man, but failures in bed occur sometimes – age issue. When I feel that something goes wrong, I take Gen Cialis as per doctor’s prescription. I don’t need therapy course or constant administration. No side-effects on my part…

William

I am 49. When I treated prostatitis, my erection weakened each day. My urologist recommended Generic Cialis. I took it several times and found insignificant nasal congestion which disappeared with time. All in all, Cialis has a good effect, I am satisfied.

Philip

I’ve been suffering from diabetes rather long. I was going to give up sex as a hopeless case. Well… I even wanted it much less, cause I’m 40 by the way. But life without sex is awful and senseless. And my wife is still hot and wants to be loved. So, I read a lot of reviews about Generic Cialis. It’s embarrassing to go to drug store, and I purchased it from online pharmacy. Tried right away – and it really helps! Just like in advertisement 😉.

Graham

I am 38 and appeared to have sexual problems lately. I visited a specialist who directed me to undergo loads of tests and finally stated that the causes are ecology and stressful situation. He prescribed Cialis for 1-2 months. The price is way tooo expensive for me. But I decided to try it and was not disappointed. One pill is ok, but purchasing the tablets for 2 months is not acceptable. Surfed a bit and got info on generics and Indian Cialis and took to test 10pcs. The same effect! I took the whole pack and today I’m going to order another one. Forgot to mention side-effects: always have stuffed nose and once had a flank pain.

Ru

I took a half of Cialis pill around 10PM. In half an hour, I felt sudden increase of blood pressure. I know the symptoms of hypertension, but do not suffer from it. Then I stopped paying attention to it. In about 2 hours I had sex and it was excellent. The boner was like a rock! After the first time, I had sex in 30 min, but it took me long to come. Then we fell asleep and went on in the morning. The boner was not worse that at night. I am more than satisfied and will order it in the future.

Adverse Effects

After the intake of Generic Cialis, main side-effects may be headache. In some cases, this pain doesn’t stop until the medication’s intake is not terminated. Nevertheless, in the majority of cases, the issue is solved by means of palliative for headaches. Also, some patients noted that Generic Cialis caused backache or pain in muscles. But these cases were reported seldom.

Most men stated that administration of Generic Cialis provoked various gastric disorders, such as pain in stomach, heaviness in abdomen, gases, or dyspepsia symptoms. Around 1% of patients had eye edema, conjunctivitis, pain in eyes or blurred vision.

Some patients observed various allergic reactions, but they had short-term or mild character. The problem is solved either by means of antihistaminic or by termination of the main medication. Some patients report that after the administration of medicine, they experienced a more frequent perspiration. The problem is solved by Generic Cialis termination. Patients who underwent diseases of cardio-vascular system reported chest pain. But since the symptoms are very weak and vague, it is not quite clear whether the pain was due to Generic Cialis or cardio-vascular system functioning while sex.

The medication should be administered by men suffering from renal failure only under the control of the doctor, whereas patients who are on hemodialysis should either refuse this drug, or conduct a Cialis-clearance-therapy along with a physician. It should be taken into account that Generic Cialis has vasodilatory functions causing arterial blood pressure drop. Therefore, before the intake of this medicine, this factor must be discussed with attending doctor.

Overdose may take place either due to incorrect prescription or due to erroneous Generic Cialis administration by a patient himself. All symptoms of overdose lie in long-term action of the medicine. Special therapy is not conducted, since symptomatic treatment is quite enough.

Symptomatic treatment for relief of Generic Cialis side-effects due to overdose lies in application of local medicines and therapy methods.

Drug and Food Interaction

Tadalafil is generally metabolized with participation of enzyme CYP3 A4. Selective inhibitor of CYP3 A4, ketoconazole, increases area under concentration-time curve by 107%, whereas rifampicine decreases it by 88%. Notwithstanding the fact that specific interactions were not studied, it may be suggested that proteases inhibitors, such as ritonavir and saquinavir; and CYP3 A4 inhibitors, such as erythromycin and itraconazole boost tadalafil’s activity.

Co-administration of antacid (magnesium hydroxide/ aluminium hydroxide) with tadalafil decreases the rate of tadalafil absorption without change of area under concentration-time curve. Increase of stomach pH resulting from the intake of H2-antagonist, nizatidine hasn’t taken significant impact on tadalafil pharmacokinetics.

Tadalafil enhances hypotensive action of nitrates. This occurs due to additive action of nitrates and tadalafil on metabolism of nitrogen oxide and cyclic guanosine monophosphate. Therefore, usage of Generic Cialis along with nitrates is strictly forbidden. The medicine doesn’t take any clinically significant action on medicines’ clearance the metabolism of which occurs with participation of isoenzyme of cytochrome P450. Research studies have stated that tadalafil doesn’t inhibit or induce such isoenzymes as CYP3 A4, CYP1 A2, CYP2 D6, CYP2 E1, and CYP2 C9.

Tadalafil doesn’t take clinically significant impact on pharmacokinetics of S-warfarin or R-warfarin. Tadalafil doesn’t influence wafarin’s action in regards to self-thromboplastin-prothrombin time. Tadalafil doesn’t prolong the duration of bleeding caused by acetosalicylic acid.

Tadalafil doesn’t interact with main classes of antihypertensive remedies, including calcium channel-blocking agents (amlodipine), inhibitors of angiotensine transforming enzyme (enalapril), beta adrenergic blocking agents (metoprolol), alpha adrenergic blocking agents, thiazide-type diuretics, and Angiotensin II Receptor Blockers which were used in various doses as monotherapy or in combinations.